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Skip Navigation LinksHome > Clostripain for Tissue Dissociation and Cell Isolation
Clostripain for Tissue Dissociation and Cell Isolation
CRESCENT CHEMICAL CO., INC. is the distributor of NORDMARK COLLAGENASE NB, NEUTRAL PROTEASE NB and CLOSTRIPAIN NB enzymes in the Americas. Clostripain NB is, in combination with Collagenase NB 1 Premium Grade and Neutral Protease NB enzymes, especially suited for isolation of islets of Langerhans from human pancreas. Clostripain NB can also be used in combination with Collagenase NB 4 Standard Grade and NB 8 Broad Range Grade to increase cell isolation efficiency and yields from several other human or animal tissues.

NORDMARK CLOSTRIPAIN NB FROM CLOSTRIDIUM HISTOLYTICUM NORDMARK CLOSTRIPAIN NB ENZYME - FINE TUNE YOUR CELL ISOLATION Clostripain also known as Clostridiopeptidase B or Endoproteinase Arg-C is a proteinase that cleaves peptide bonds on the carboxyl side of arginine. This protein is a heterodimer composed of a heavy and a light chain that are held together via strong noncovalent forces. As a proteolytic enzyme it can be used for isolation of various cell types by tissue dissociation. Clostripain exists in two different forms, an oxidized, native condition and a reduced activated form that differ in enzymatic activity. The native clostripain can be activated with reducing agents (e.g. DTT, Cysteine) resulting in a higher activity of the enzyme. Clostripain NB is used in combination with purified Collagenase NB 1 Premium Grade (Cat. no. S1745503) and/or Neutral Protease NB (Cat. No. S3030112) as well as Collagenase NB 4 Standard Grade (Cat. no. S1745401) or Collagenase NB 8 Broad Range (Cat. no. S1745601). For research use only.

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