Nordmark Clostripain NB
Clostripain, also known as Clostridiopeptidase B or Endoproteinase Arg-C, is a proteinase that cleaves peptide bonds on the carboxyl side of arginine. This protein is a heterodimer composed of a heavy and a light chain that are held together via strong noncovalent forces. As a proteolytic enzyme it can be used for isolation of various cell types by tissue dissociation.
Clostripain exists in two different forms: an oxidized, native condition and a reduced activated form that differ in enzymatic activity. The native clostripain can be activated with reducing agents (e.g. DTT, Cysteine), resulting in a higher activity of the enzyme.
Clostripain NB is used in combination with purified Collagenase NB 1 Premium Grade and/or Neutral Protease NB, as well as Collagenase NB 4 Standard Grade or Collagenase NB 8 Broad Range.
For information and samples please contact us at:
Crescent Chemical Co., Inc.
2 Oval Dr.
Islandia, NY 11749