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Crescent Chemical Co., Inc. supplies NORDMARK CLOSTRIPAIN NB. Clostripain also known as Clostridiopeptidase B or Endoproteinase Arg-C is a proteinase that cleaves peptide bonds on the carboxyl side of arginine. This protein is a heterodimer composed of a heavy and a light chain that are held together via strong noncovalent forces. As a proteolytic enzyme it can be used for isolation of various cell types by tissue dissociation. Clostripain exists in two different forms, an oxidized, native condition and a reduced activated form that differ in enzymatic activity. The native clostripain can be activated with reducing agents (e.g. DTT, Cysteine) resulting in a higher activity of the enzyme. Clostripain NB is used in combination with purified Collagenase NB 1 Premium Grade and/or Neutral Protease NB as well as Collagenase NB 4 Standard Grade or Collagenase NB 8 Broad Range.

Clostripain, the Missing Link in the Enzyme Blend for Efficient Human Islet Isolation
2017 - IPITA Islet Isolation
Synergistic Effect of Neutral Protease and Clostripain on Rat Pancreatic Islet Isolation

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